CardioGraft Clinical Evidence

For over 40 years, LifeNet Health has been the global leader in cardiac allografts. Our CardioGraft^® implants deliver the high-quality and proven performance you expect for all of your procedures. The list of articles below demonstrates the efficacy of our cardiac solutions.

Peer-reviewed Publications

Decellularized vs Non-decellularized Allogeneic Pulmonary Artery Patches for Pulmonary Arterioplasty  Carlos Bonilla-Ramirez, Varun Aggarwal, Manasa Atyam, Athar M. Qureshi, Jeffrey S. Heinle, E. Dean McKenzie, Decellularized vs Non-decellularized Allogeneic Pulmonary Artery Patches for Pulmonary Arterioplasty, Seminars in Thoracic and Cardiovascular Surgery,2022, ISSN 1043-0679, https://doi.org/10.1053/j.semtcvs.2022.07.005. Article in Review.

The Ross/Ross-Konno procedure in infancy is a safe and durable solution for aortic stenosis.

Luxford JC, Ayer JG, Betts K, et al. The Ross/Ross-Konno procedure in infancy is a safe and durable solution for aortic stenosis. J Thorac Cardiovasc Surg. 2022;163(2):365-375. doi:10.1016/j.jtcvs.2021.06.066. Article in Review.

 

Pulmonary arterioplasty with decellularized allogeneic patches.

Hopkins RA, Lofland GK, Marshall J, et al. Ann Thorac Surg. 2014. 97(4):1407–1412. 

 

Performance and Durability of Cryopreserved Allograft Aortic Valve Replacements

Witten JC, Durbak E, Houghtaling PL, Unai S, Roselli EE, Bakaeen FG, Johnston DR, Svensson LG, Jaber W, Blackstone EH, Pettersson GB. Ann Thorac Surg. 2021. 111(6):1893-1900. Article in Review. 

 

Aortic Allograft Infection Risk

Witten JC, Houghtaling PL, Shrestha NK, Gordon SM, Jaber W, Blackstone EH, Pettersson GB; Infectious Endocarditis Working Group. J Thorac Cardiovasc Surg. 2021 May 12:S0022-5223(21)00791-1. Article in Review

 

Long-term Outcomes of Aortic Valve Replacement with Aortic Homograft: 27 Years Experience

Yazdchi F, Harloff M, Hirji S, Percy E, McGurk S, Cherkasky O, Malarczyk A, Newell P, Rinewalt D, Mallidi HR, Sabe AA, Aranki S, Shekar P, Kaneko T. Ann Thorac Surg. 2021: S0003-4975(21)00048-5. Article in Review. 

 

Initial Pediatric Cardiac Experience With Decellularized Allograft Patches.

Lofland GK, O'Brien JE Jr, Gandy KL, et al. Ann Thorac Surg. 2012. 93(3):968–971.

 

Clinical Utility of Preimplantation Homograft Cultures in Patients Undergoing Congenital Cardiac Surgery

Mehrotra P, Quinonez LG, Surana NK, Pollock N, Sandora TJ. J Pediatric Infect Dis Soc. 2017. 6(2):202–204.

 

Pathology of Valved Venous Homografts Used as Right Ventricle-to-Pulmonary Artery Conduits in Congenital Heart Disease Surgery

Carreon CK, Benini A, Baird C, et al. J Thorac Cardiovasc Surg. 2019. 157(1):342–350.e3.

 

Risk Factors for Development of Endocarditis and Reintervention in Patients Undergoing Right Ventricle to Pulmonary Artery Valved Conduit Placement

Mery CM, Guzmán-Pruneda FA, De León LE, et al. J Thorac Cardiovasc Surg. 2016. 151(2):432–441.e4412.

 

Homograft Use in Reoperative Aortic Root and Proximal Aortic Surgery for Endocarditis: A 12-year Experience in High‑risk Patients

Preventza O, Mohamed AS, Cooley DA, et al. J Thorac Cardiovasc Surg. 2014. 48(3):989–994.

 

Reoperative Right Ventricular Outflow Tract Conduit Reconstruction: Risk Analyses at Follow Up

Rodefeld MD, Ruzmetov M, Turrentine MW, Brown JW. J Heart Valve Dis. 2008. 17(1):119–126.

 

Reconstruction of Right Ventricular Outflow Tract in Neonates and Infants Using Valved Cryopreserved Femoral Vein Homograft

Schiller O, Sinha P, Zurakowski D, Jonas RA. J Thorac Cardiovasc Surg. 2014. 147(3):874–879.

 

Tolerance to Incompatible ABO Blood Group Antigens Is Not Observed Following Homograft Implantation

Feingold B, Raval JS, Galambos C, et al. Hum Immunol. 2011. 72(10):835–840.

 

 

General Supporting Publications

White Paper: Aortic Allografts: Bigger is not always better!  James C. Witten, MD, Cleveland Clinic Department of Thoracic and Cardiovascular Surgery, Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH

Surgery or endovascular therapy for chronic limb-threatening ischemia. Farber, A., Menard, M. T., Conte, M. S., Kaufman, J. A., Powell, R. J., Choudhry, N. K., ... & Rosenfield, K. (2022). New England Journal of Medicine. 

Pulmonary Valve Replacement Function in Adolescents: A Comparison of Bioprosthetic Valves and Homograft Conduits

Batlivala SP, Emani S, Mayer JE, McElhinney DB. Ann Thorac Surg. 2012. 93(6):2007–2016.

 

Results of Allograft Aortic Valve Replacement for Complex Endocarditis

Dearani JA, Orszulak TA, Schaff HV, Daly RC, Anderson BJ, Danielson GK. J Thorac Cardiovasc Surg. 1997. 113(2):285–291.

 

Reconstruction of the RVOT with Valved Biological Conduits: 25 Years Experience with Allografts and Xenografts

Homann M, Haehnel JC, Mendler N, et al. Eur J Cardiothorac Surg. 2000. 17(6):624–630.

 

Intermediate-term Fate of Cryopreserved Allograft and Xenograft Valved Conduits

Kirklin JW, Blackstone EH, Maehara T, et al. Ann Thorac Surg. 1987. 44(6):598–606.

 

Results of Homograft Aortic Valve Replacement for Active Endocarditis

Tuna IC, Orszulak TA, Schaff HV, Danielson GK. Ann Thorac Surg. 1990. 49(4):619–624.

 

Surgical Treatment of Active Infective Aortic Valve Endocarditis With Associated Periannular abscess--11 Year Results

Knosalla C, Weng Y, Yankah AC, et al. Eur Heart J. 2000. 21(6):490–497.

 

Surgical Management of Acute Aortic Root Endocarditis with Viable Homograft: 13-year Experience

Yankah AC, Klose H, Petzina R, Musci M, Siniawski H, Hetzer R. Eur J Cardiothorac Surg. 2002. 21(2):260–267.

 

Mid-Term Results of Reconstruction of the Right Ventricular Outflow Tract Using Cryopreserved Homografts

Youn YN, Park HK, Kim DK, Park SY, Yi G, Park YH. Yonsei Med J. 2007. 48(4):639–644.