The world’s most versatile osteobiologic.
Many commercial DBMs utilize an inert carrier to improve handling, and the proportion of demineralized bone content in the graft varies widely by manufacturer. These carriers do not have a biological function, and they can dilute the osteoinductive potential of the graft.1 In addition, carriers can negatively affect the release of growth factors2 and functionality of native cells.3 PliaFX contains 100% bone and provides optimized handling without compromising the osteoconductive and osteoinductive properties necessary for bone formation.
1. Han B, Tang B, Nimni ME. Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix. J Orthop Res. 2003;21(4):648-654.
2. Lee JH, Baek H-R, Lee KM, et al. The Effect of Poloxamer 407-Based Hydrogel on the Osteoinductivity of Demineralized Bone Matrix. Clinics in Orthopedic Surgery. 2014;6(4):455-461.
3. Murphy MB, Suzuki RK, Sand TT, Chaput CD, Gregory CA. Short Term Culture of Human Mesenchymal Stem Cells with Commercial Osteoconductive Carriers Provides Unique Insights into Biocompatibility. J Clin Med. 2013;2(3):49-66.