Tecnología de descelularización Matracell

El proceso Matracell, utilizado en aloinjertos dérmicos, brinda una estructura fuerte y acelular que facilita la migración, proliferación y vascularización celulares. Únicamente los tejidos procesados con la tecnología Matracell alcanzan el umbral de la descelularización completa, lo que disminuye la probabilidad de una respuesta inmunitaria.

 

Aunque varios productos dérmicos afirman que son “descelularizados”, no todos los procesos de descelularización cumplen con la definición desarrollada por Crapo, Gilbert y Badylak.¹ Después de evaluar las respuestas a la remodelación y las respuestas adversas de las células y los huéspedes, los autores determinaron que la ADM debe contener menos de 50 ng de ADN por mg para cumplir con el propósito de la descelularización. Solo el tejido tratado con Matracell cumple con ese criterio.

 

Artículos Revisados por Colegas

• Biological incorporation of human acellular dermal matrix used in Achilles tendon repair. Cell Tissue Bank. 2017

• Abdominal Wall Allograft Preclinical Biomechanical Investigation of a Novel Reconstructive Adjunct. Annals of Plastic Surgery. 2017

• Osteochondral Allograft Transplantation Using the Chondrofix Implant. Oper Tech Sports Med. 2013

• Macrophage phenotypes correspond with remodeling outcomes of various acellular dermal matrices. Open Journal of Regenerative Medicine. 2012

• Properties of Biologic Scaffolds and Their Response to Mesenchymal Stem Cells. Arthroscopy. 2014 

• Prototype Anionic Detergent Technique Used to Decellularize Allograft Valve Conduits Evaluated in the Right Ventricular Outflow Tract in Sheep. J Heart Valve Dis. 2014

• From cadaver harvested homograft valves to tissue-engineered valve conduits. Progress in Pediatric Cardiology. 2006

• Decellularization reduces calcification while improving both durability and 1-year functional results of pulmonary homograft valves in juvenile sheep. The Journal of Thoracic and Cardiovascular Surgery. 2009

• Pulmonary Arterioplasty With Decellularized Allogeneic Patches. Ann Thorac Surg 2014

• Ovine panel reactive antibody assay of HLA responsivity to allograft bioengineered vascular scaffolds. Evolving Technology. 2005

• Recellularization of Decellularized Allograft Scaffolds in Ovine Great Vessel Reconstructions. Ann Thorac Surg. 2005

• Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review. Cell Tissue Bank. 2015

• Measurements of the Effects of Decellularization on Viscoelastic Properties of Tissues in Ovine, Baboon, and Human Heart Valves Tissue Eng Part A. 2012

• Biomimetic Approaches for Bone Tissue Engineering. Tissue Eng Part B Rev. 2017

• Organ engineering based on decellularized matrix scaffolds. Trends in Molecular Medicine. August 2011

• Viral Inactivation of Human Osteochondral Grafts with Methylene Blue and Light. Cartilage. 2014​

Documentos y Textos Técnicos

• Ensuring the Safety of Allograft Dermal Tissue
• Matracell Decellularized Allograft Bio-implants – Critical Applications for Cardiovascular Surgery

• Decellularization of Human Dermis Using Matracell® Technology: Process, Preclinical Studies, and Medical Application Biomechanical Properties of Tendon Augmentation Materials