Matracell Decellularization Technology

The Matracell process — utilized in dermal allografts — yields a strong, acellular scaffold that facilitates cell proliferation, cell migration and vascularization. Only tissue processed with Matracell technology meets the threshold of being truly decellularized, minimizing the possibility of an immune response.

Although several dermal products claim to be “decellularized”, not all decellularization processes meet the definition developed by Crapo, Gilbert, and Badylak.1 After evaluating remodeling responses and adverse cell and host responses, the authors determined that an ADM needs to contain less than 50ng dsDNA/mg to satisfy the intent of decellularization. Only Matracell‑treated tissue meets that criteria.

Peer Reviewed Articles

• Agrawal H, Tholpady SS, Capito AE, Drake DB, Katz KJ. Macrophage phenotypes correspond with remodeling outcomes of various acellular dermal matrices. Open Journal of Regenerative Medicine. 2012;1(3):51-59. Doi: 10.4236/ojrm.2012.13008

• Capito AE, Tholpady SS, AgrawalH, Drake DB, Katz AJ. Evaluation of host tissue integration, revascularization, and cellular infiltration within various dermal substrates. Annals of Plastic Surgery. 2012. 68(5): 495-500. Doi: 10.1097/SAP.0b013e31823b6b01

• Hopkins RA, Lofland GK, Marshall J, Connelly D, Acharya G, Dennis P, Stroup R, McFall C, O'Brien JE Jr. Pulmonary arterioplasty with decellularized allogeneic patches. Ann Thorac Surg. 2014 Apr;97(4):1407-12. doi: 10.1016/j.athoracsur.2013.12.005

• Moore MA, Samsell B, Wallis G, Triplett S, Chen S, Jones AL, Qin X. Decellularization of human dermis using non-denaturing anionic detergent and endonuclease: a review. Cell Tissue Bank. 2015 Jun;16(2):249-59. doi: 10.1007/s10561-014-9467-4

• Beitzel K, McCarthy MB, Cote MP, Russell RP, Apostolakos J, Ramos DM, Kumbar SG, Imhoff AB, Arciero RA, Mazzocca AD. Properties of biologic scaffolds and their response to mesenchymal stem cells. Arthroscopy. 2014 Mar;30(3):289-98. doi: 10.1016/j.arthro.2013.11.020

• Crapo PM, Gilbert TW & Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials. 2011 April;32(12):3233-3243. Doi: 10.1016/j.biomaterials.2011.01.057

White Papers and Technical Papers

• Ensuring the Safety of Allograft Dermal Tissue
• Matracell Decellularized Allograft Bio-implants – Critical Applications for Cardiovascular Surgery

• Decellularization of Human Dermis Using Matracell® Technology: Process, Preclinical Studies, and Medical Application Biomechanical Properties of Tendon Augmentation Materials

1. Crapo PM, Gilbert TW & Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials. 2011. April;32(12):3233-3243